کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1399490 | 1501186 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones](/preview/png/1399490.png)
In the present investigation, a series of novel 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones were prepared with the objective of developing better antimicrobial agents. The chemical structures of the newly synthesized compounds were characterized by spectral (IR, 1H NMR, 13C NMR and LCMS) methods. The newly synthesized compounds (4a–i) and (5a–e, 5h) were screened for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. The antifungal activity was tested against Rhizopus oryzae, Aspergillus niger, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae. Among all the compounds synthesized, compounds 4d and 5b exhibited significant antibacterial activity.
Synthesis, characterization, antibacterial and antifungal properties of some novel 1,2,4-triazol-3-ones have been described.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 8, August 2010, Pages 3329–3334