کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399503 1501186 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines
چکیده انگلیسی

A series of novel dispiropyrrolidines have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from sarcosine and isatin with the dipolarophile 3-benzylidene-1-methyl-pyrrolidine-2,5-dione. Their antibacterial activity was evaluated against Bacillus subtilis NCIM 2718, Staphylococcus aureus NCIM5021, Salmonella typhi NCIM2501, Pseudomonas aeruginosa NCIM 5029 and Proteus vulgaris NCIM2813 by two fold dilution method. Compound 6e exhibits reasonably good activity and compound 6c exhibits poor activity against all the organisms. The QSAR’s were developed for all antibacterial activities. The models had either one or two descriptors (r2 = 0.81–0.97, radj2=0.75–0.96, q2 = 0.57–0.92, F-ratio = 12.73–162.76). Topology, shape, charge distribution and hydrophobic nature of the molecules had pronounced effect on their antibacterial activity.

A series of novel dispiropyrrolidines have been synthesized through 1,3-dipolar cycloaddition of azomethine ylide. The products exhibits good antibacterial activity and QSAR were developed for the antibacterial activities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 8, August 2010, Pages 3446–3452
نویسندگان
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