کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1399556 | 1501190 | 2010 | 6 صفحه PDF | دانلود رایگان |
The purpose of the present work was to investigate, following previous works, naphthylchalcones as antihyperglycemic agent in glucose loaded animal model, insulin secretion as well as the action of these compounds on glucose uptake in a target tissue of insulin. The naphthylchalcones were found to have an acute serum glucose-lowering effect in hyperglycemic normal rats. In addition, chalcones 2 and 4 stimulated significantly the insulin secretion induced by glucose. These results suggest that the presence of nitro group and their position in the phenyl rings are responsible for the antihyperglycemic activity of chalcones. Additionally, the effect of chalcones on serum glucose-lowering seems to be a consequence of insulin secretion and these chalcones represent potential compounds with strong antihyperglycemic properties.
Chalcone 2 (2E)-3-(2-naphtyl)-1-(4′-nitrophenyl)-2-propen-1-one and chalcone 4 (2E)-1-(2- naphtyl)-3-(3-nitrophenyl)-2-propen-1-one showed stimulatory effect in insulin secretion and represent potential compounds with strong antihyperglycemic properties.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1332–1337