کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399571 1501190 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and in vitro pharmacology of novel pregabalin derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, characterization and in vitro pharmacology of novel pregabalin derivatives
چکیده انگلیسی

A series of novel pregabalin derivatives were synthesized starting from N-protected pregabalin, different amino sugars, adamantylamine, serotonin and tryptamine. New compounds were spectroscopically characterized and in vitro tested on gabapentin receptor binding assay. The serotonin-pregabalin adduct showed significant binding effect and its IC50 value was determined.

A series of novel pregabalin derivatives were synthesized starting from N-protected pregabalin, different amino sugars, adamantylamine, serotonin and tryptamine. Gabapentin receptor binding assay study showed the one among them, the serotonin-pregabalin adduct 17, possesses a promising activity (Ki = 11 μM).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1447–1452
نویسندگان
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