Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates

New hetero(μ3-oxo)trinuclear iron(III) furoates with the general formulas [Fe2MO(α-Fur)6(L)(H2O)2], where L = THF (1–3), DMF (4–5), M = Mn2+ (1, 4), Co2+ (2, 5), Ni2+ (3, 6) and [Fe2MO(α-Fur)6(3Cl-Py)3], where M = Mn2+ (7), Co2+ (8), Ni2+ (9); have been synthesised and investigated by Mössbauer and IR spectroscopies. The X-ray crystal structure has been determined for the 4 and 8 complexes, indicating that they are related to the monoclinic crystal system (P21/n) and have a structure typical of μ3-O-bridged trinuclear iron (III) compounds. The 57Fe Mössbauer spectra of microcrystalline samples of the compounds indicate the presence of high-spin iron (III) (S = 5/2) with a near symmetrical environments. The iron(III)–cobalt(II) containing compounds 2, 5 and 8 displayed MIC values between 0.83 ÷ 4.00 μg/mL.

New hetero(μ3-oxo)trinuclear iron (III) furoates have been prepared and investigated by X-ray, Mössbauer and IR spectroscopies. It was shown that the iron(III)–cobalt(II) containing compounds with furoate ligand exhibited high anti-tuberculosis activity, which is unexpected result for these class of compounds.Figure optionsDownload as PowerPoint slide