کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1399578 | 1501190 | 2010 | 8 صفحه PDF | دانلود رایگان |
A series of heterocyclic derivatives 2–16 conjugated with tetrahydronaphthalene moiety were synthesized as antiviral agents by using 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone as starting material. The antiviral screening showed that many of these obtained compounds have good antiviral activities comparable to Acyclovir as reference control. Two compounds 13 and 15 gave over 90% inhibition and considered to be highly promising and on confirming their activity and comparing them to antiviral activity of Acyclovir. The detailed synthesis, spectroscopic data, and antiviral screening for synthesized compounds were reported.
A series of heterocyclic derivatives 2–16 conjugated with tetrahydronaphthalene moiety were synthesized as antiviral agents by using 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone as starting material. The antiviral screening showed that many of these obtained compounds have good antiviral activities comparable to Acyclovir as reference control. Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 4, April 2010, Pages 1494–1501