Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines

Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg Ka values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives.

A series of phenylbenzoimidazole and benzoimidazo[1,2-c]quinazoline derivatives were synthesized and tested for their DNA affinity by the ethidium bromide displacement assay. The lg Ka values of the compounds 1 are approximately one order magnitude greater than corresponding derivatives 2.Figure optionsDownload as PowerPoint slide