کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399702 1501210 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones
چکیده انگلیسی

A new series of oxazolidinones bearing N-linked 5-triazolylmethyl group have been synthesized and their in vitro antibacterial activities (MIC) were evaluated against a spectrum of resistant and susceptible Gram-positive organisms. Some of the analogues in this series displayed activity superior to linezolid and vancomycin. Furthermore, in vivo efficacies and pharmacokinetic properties of the selected compounds were also disclosed herein; the selected compounds showed reasonable bioavailability as well as in vivo efficacy comparable to that of linezolid.

A new series of oxazolidinones bearing N-linked 5-triazolylmethyl group are disclosed. The selected compounds of this series display in vitro and in vivo activities comparable to linezolid. Compound 4e shows excellent activity against Gram-positive organisms.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 8, August 2008, Pages 1706–1714
نویسندگان
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