کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399705 | 1501210 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of potential Rho-kinase inhibitors based on the chemistry of an original heterocycle: 4,4-Dimethyl-3,4-dihydro-1H-quinolin-2-one Synthesis of potential Rho-kinase inhibitors based on the chemistry of an original heterocycle: 4,4-Dimethyl-3,4-dihydro-1H-quinolin-2-one](/preview/png/1399705.png)
A new series of substituted 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one have been prepared via condensation of 3,3-dimethylacryloyl chloride with aniline. Details of synthetic procedures are shown. Our aim was to investigate the potency of our original heterocycle in the inhibition of the Rho-kinase enzyme, known to be of major importance in the cascade reactions leading to arterial hypertension. Biological activity for the seven compounds has been investigated and is presented.
A new series of substituted 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one have been synthesized. The seven compounds obtained were tested in the inhibition of the Rho-kinase enzyme known to be of major importance in the cascade reactions leading to arterial hypertension.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 8, August 2008, Pages 1730–1736