Carbamate prodrugs of N-alkylfuramidines

The synthesis and evaluation of 2,5-bis[4-(N-ethoxycarbonyl-N′-isopropyl)amidinophenyl]furan, 2,5-bis[4-(N-2,2,2-trichloroethoxycarbonyl-N′-isopropyl)amidinophenyl]furan and 2,5-bis[4-(N-cyclopentyl-N′-2,2,2-trichloroethoxycarbonyl)amidinophenyl]furan as prodrugs of bis-N-alkylamidines are reported. The results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for Pneumocystis pneumonia.

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