کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399912 | 1501225 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
ortho-Acylation attempt of benzenesulfonamide afforded the corresponding hemiaminal as major product. The in situ reduction of the reaction mixture, reported herein, directly provided 2-hydroxyalkyl benzenesulfonamide, an important pharmacophoric element for designing drug-like scaffolds. Its application is demonstrated through designing a novel series of 1,5-diarylpyrazoles for cyclooxygenase-2 (COX-2) inhibition.
The hemiaminals obtained as a major product during ortho-acylation attempt of benzenesulfonamide were in situ reduced to pharmacophoric 2-hydroxyalkyl benzenesulfonamide intermediates and used in designing drug-like scaffolds.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 4, April 2007, Pages 456–462
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 4, April 2007, Pages 456–462
نویسندگان
Sunil K. Singh, S. Shivaramakrishna, V. Saibaba, K. Srinivas Rao, K. Ravi Ganesh, R. Vasudev, P. Praveen Kumar, J. Moses Babu, K. Vyas, Y. Koteswar Rao, J. Iqbal,