کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399912 1501225 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: A single-step synthesis from benzenesulfonamide via hemiaminal
چکیده انگلیسی

ortho-Acylation attempt of benzenesulfonamide afforded the corresponding hemiaminal as major product. The in situ reduction of the reaction mixture, reported herein, directly provided 2-hydroxyalkyl benzenesulfonamide, an important pharmacophoric element for designing drug-like scaffolds. Its application is demonstrated through designing a novel series of 1,5-diarylpyrazoles for cyclooxygenase-2 (COX-2) inhibition.

The hemiaminals obtained as a major product during ortho-acylation attempt of benzenesulfonamide were in situ reduced to pharmacophoric 2-hydroxyalkyl benzenesulfonamide intermediates and used in designing drug-like scaffolds.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 4, April 2007, Pages 456–462
نویسندگان
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