Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids

With an intention to synergise the antibacterial activity of chalcones and oxazolidinones, several hybrid compounds possessing both chalcone and oxazolidinone moieties were synthesized and tested for antibacterial activity. The hybrid molecules containing heterocycles instead of aromatic ring were found to be active. A SAR study with various heterocycles resulted in a lead molecule 20, which was converted to one of the potent antibacterial compounds 27.

The design, synthesis and SAR studies on a series of novel chalcone–oxazolidinone hybrids are reported that resulted in certain potent antibacterial compounds.Figure optionsDownload as PowerPoint slide