کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399950 1501227 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position
چکیده انگلیسی

Eleven C2-substituted derivatives of resveratrol (trans-3,4′,5-trihydroxystilbene, RES) were prepared by partial synthesis from RES and evaluated for their cytotoxic activities against a human nasopharyngeal epidermoid tumor cell line KB. Among them, compounds 2 and 3 were more active than 5-fluorouracil (5-FU), an anticancer drug, and compound 5f exhibited similar activity to 5-FU. On the basis of the biological results, structure–activity relationships were discussed.

A series of resveratrol derivatives were prepared by the partial synthesis and evaluated for their cytotoxic activities against a human nasopharynyeal epidermoid tumor cell line KB.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 2, February 2007, Pages 263–267
نویسندگان
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