کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1400026 1501232 2006 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme
چکیده انگلیسی

About 12 glycosides prepared through amyloglucosidase catalysis and 23 amino acyl esters of carbohydrates prepared through lipase catalysis in organic solvents showed angiotensin converting enzyme (ACE) inhibition activity. Both amino acyl esters of carbohydrates and glycosides exhibited IC50 values for ACE inhibition in the 0.5 mM to 15.7 mM range. Eugenyl-d-glucoside (IC50: 0.5 ± 0.04 mM), l-isoleucyl-d-glucose (IC50: 0.7 ± 0.067 mM), vanillyl-d-sorbitol (IC50: 0.8 ± 0.09 mM), l-histidyl-d-fructose (IC50: 0.9 ± 0.087 mM), l-tryptophanyl-d-fructose (IC50: 0.9 ± 0.092 mM), octyl-d-glucoside (IC50: 1.0 ± 0.093 mM), vanillyl-d-mannoside (IC50: 1.0 ± 0.089 mM), l-valyl-d-mannitol (IC50: 1.0 ± 0.092 mM) and l-phenylalanyl-d-glucose (IC50: 1.0 ± 0.089 mM) were the compounds, which showed the best ACE inhibitory activities.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 9, September 2006, Pages 1059–1072
نویسندگان
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