Supercritical antisolvent synthesis of fine griseofulvin particles

Supercritical carbon dioxide (scCO2) was used as antisolvent to precipitate griseofulvin (GF), an orally administered antifungal drug, from methylene chloride (DCM) using the supercritical antisolvent (SAS) process. The influence of different operating parameters such as antisolvent addition rate, temperature, concentration, and solution addition rate on product characteristics (particle size and size distribution, and morphology) has been analyzed. This investigation shows that with an adequate selection of process conditions it is possible to selectively produce crystalline needle-shaped particles with narrow size distribution.

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► In this study, the effect of the SAS process parameters were investigated.
► GF is an orally administered antifungal drug.
► The higher the antisolvent addition rate, the smaller the size of the particles.
► The gained results necessitate further investigation into the SAS process.