Preparation of Poly(l-Lactic Acid) Microencapsulated Vitamin E

Poly(l-lactic acid) (PLLA) microencapsulated vitamin E was prepared in oil in water (O/W) emulsion system using solvent evaporation technique. The influence of PLLA:vitamin E weight ratio on the encapsulation was studied. In the case of low molecular weight PLLA, the optimum ratio is 25:1. It was found that using smaller amount of PLLA, microcapsule could not formed. In contrast, vitamin E was well enveloped with lower amount of high molecular weight PLLA, PLLA:vitamin E at 3:1. The obtained capsule was observed with an optical and scanning electron microscopes. The amount of the encapsulated vitamin E was measured with gel permeation chromatograph.