Response surface optimization of the operating parameters for a complex distillation column based on process simulation

The effects of operating parameters on the performance of a prefractionator in solvent fermentation were studied by process simulation. Effects of feed position, side stream position and flow rate, overhead reflux rate and cooling temperature on the total solvent content in the bottom residue were investigated. These parameters were further optimized by response surface analysis according to the principles of central composite design (CCD), with the minimization of total solvent content in the bottom residue as the objective. A mathematical model for the correlation of total solvent content and operating parameters was established in the optimization, and the optimized results were verified by both simulation and experiments. Results showed that the response surface approach is more advantageous than single-factor analysis in the optimization of complex distillation columns, and the simulated results agreed well with the experimental data.