Preparation of Encapsulated Magnetite Microparticles with Hydroxyapatite

Apatite Nuclei were synthesized by raising pH of simulated body fluid (SBF). The Apatite Nuclei were attached to the surfaces of magnetite microparticles. By the soak in SBF, hydroxyapatite was induced from the Apatite Nuclei and covered the whole surface area of the magnetite microparticles, and then encapsulated magnetite microparticles with hydroxyapatite were fabricated. The encapsulated magnetite microparticles with hydroxyapatite were soaked in saline and changes in Fe concentration in saline were measured. Hydroxyapatite encapsulating magnetite microparticles inhibited elution of Fe from magnetite