Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair

• Current cell-based strategies are significantly limited by biomaterial carriers.
• We highlight considerations for engineering the cell delivery microenvironment.
• We discuss strategies to improve cell delivery and engraftment in tissue repair.

Cell-based therapies represent promising strategies for tissue repair, particularly in cases in which host cells, due to disease, age, or excessive trauma, are unable to repair the defect or deficiency alone, even with additional delivered therapeutics. Current cell therapies fail to address long-term engraftment or delivery timing and location and result in modest improvements with long term engraftment rates of less than 1%. In many cell therapy applications, an appropriate carrier must be used to deliver transplanted cells and promote cell engraftment and function for a successful outcome by providing the appropriate microenvironment for the interactions between transplanted and host cells. This review highlights important considerations for engineering the microenvironment for cell delivery and engraftment in tissue repair.

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