کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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157021 | 456957 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye](/preview/png/157021.png)
Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the posterior eye from an implant, made of poly(N-isopropylacrylamide) (NIPAM) and placed episclerally, is presented. The thermally sensitive gel is modelled as a poroelastic material with a phase transition characterized by a lower critical solution temperature (LCST). The study utilizes compartments for various eye tissues, with individual compartments considered to be completely mixed and drug transport between compartments occurring by one-dimensional diffusion.
Journal: Chemical Engineering Science - Volume 65, Issue 18, 15 September 2010, Pages 5170–5177