Animal models for vascular tissue-engineering

• There is increasing demand for small diameter blood vessels as replacement grafts.
• Major roadblocks in engineered vascular grafts: cell sources and in vivo testing.
• Clinical application of vascular grafts requires testing in relevant animal models.

Because of rise in cardiovascular disease throughout the world, there is increasing demand for small diameter blood vessels as replacement grafts. The present review focuses on the animal models that have been used to test small-diameter TEVs with emphasis on the attributes of each model. Small animal models are used to test short-term patency and address mechanistic hypotheses; and large, preclinical animal models are employed to test long-term patency, remodeling and function in an environment mimicking human physiology. We also discuss recent clinical trials that employed laboratory fabricated TEVs and showed very promising results. Ultimately, animal models provide a testing platform for optimizing vascular grafts before clinical use in patients without suitable autologous vessels.

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