Vault particles: a new generation of delivery nanodevices

Vault particles possess many attributes that can be exploited in nanobiotechnology, particularly in the creation of drug delivery nanodevices. These include self-assembly, 100 nm size range, a dynamic structure that may be controlled for manipulation of drug release kinetics and natural presence in humans ensuring biocompatibility. The flexibility and the adaptability of this system have been greatly enhanced by the emerging atomic-level information and improved comprehension of vault structure and dynamics. It seems likely that this information will allow their specific tailoring to the individual requirements of each drug and target tissue. These properties provide vaults with an enormous potential as a versatile delivery platform.

Figure optionsDownload high-quality image (270 K)Download as PowerPoint slideHighlights
► Vault particles can be exploited in nanobiotechnology as drug delivery nanodevices.
► The structural information of vaults would serve as a guide for rational engineering.
► The dynamic structure of vaults may be controlled for manipulation of drug release.
► Engineered vaults allow specific cell targeting and controlled encapsulation.