Nano TiO2/SO42− as a heterogeneous solid acid catalyst for the synthesis of 5-substited-1H-tetrazoles

An efficient and economical protocol for the synthesis of 5-substituted-1H-tetrazoles from various nitriles and sodium azide is reported using nano TiO2/SO42− as an effective heterogeneous catalyst. A wide variety of aryl nitriles underwent [3 + 2] cycloaddition to afford tetrazoles in good to excellent yields.

Figure optionsDownload as PowerPoint slide