Clinical dextran purified by electric ultrafiltration coupling with solvent crystallization

A new separation method was used to control the molecular weight distribution and improve the quality of clinical dextran. Crystalline solid of dextran was precipitated in the charging basket during the membrane filtration, coupled with solvent crystallization and enhanced by a DC electric field. It was found that the permeate flux of ultrafiltration could be distinctly improved by the applied DC electric field, and the permeate flux of it could be preserved at a high and stable level. Molecular weight distribution of dextran was controlled effectively by ultrafiltration coupled with solvent crystallization. Moreover, organic solvent consumption and processing time can be saved markedly by this new technology.