کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1709615 | 1012859 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Logarithmic bounds on the posterior divergence time of two sequences
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موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مکانیک محاسباتی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
When two initially identical binary sequences undergo independent site mutations at a constant rate, the proportion of site differences is often used to estimate the total time TT that separates the two sequences. In this short note we study the posterior distribution of TT when the prior distribution on TT is exponential. We show that posterior estimates of TT (for any data) cannot grow faster than the logarithm of the sequence length, and this rate is achieved for data generated at site saturation (i.e. in the limit as T→∞T→∞). The problem is motivated by information-theoretic questions arising in molecular systematic biology, in which one wishes to use DNA sequences to estimate the divergence time between present-day species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Mathematics Letters - Volume 23, Issue 9, September 2010, Pages 975–979
Journal: Applied Mathematics Letters - Volume 23, Issue 9, September 2010, Pages 975–979
نویسندگان
Radu Mihaescu, Mike Steel,