Synthetic efforts towards the marine polyketide peloruside A

Peloruside A is a highly oxygenated marine polyketide isolated from specimens of Mycale hentscheli collected from the Pelorus Sound on the north coast of the south island of New Zealand. Due to its potent cytotoxicity and performance in initial preclinical studies, peloruside A appears to have significant chemotherapeutic potential. Isolation alone is unlikely to provide sufficient quantities of peloruside A for early clinical development. This manuscript will review the current state of synthetic efforts towards the production of peloruside A up to April 2008.