DNA aptamer technology for personalized medicine

• The development of DNA aptamers parallels that of personalized medicine.
• Both aptamer-functionalized nanomaterials and DNA nanostructures have been developed.
• They have been used for detection, diagnosis, and treatment of cancer and other diseases.
• The review focuses more on studies that demonstrate in vivo efficacy.

This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus on in vivo studies for potential clinical applications. Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases. The use of aptamers as targeting agents in drug delivery is also covered. The advantages and future directions of such DNA aptamer-based technology for the continued development of personalized medicine are discussed.

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