کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
174871 | 458900 | 2015 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Gene expression profiling of brakeless mutant Drosophila embryos Gene expression profiling of brakeless mutant Drosophila embryos](/preview/png/174871.png)
The transcriptional co-regulator Brakeless performs many important functions during Drosophila development, but few target genes have been identified. Here we use Affymetrix microarrays to identify Brakeless-regulated genes in 2–4 h old Drosophila embryos. Robust multi-array analysis (RMA) and statistical tests revealed 240 genes that changed their expression more than 1.5 fold. We find that up- and down-regulated genes fall into distinct gene ontology categories. In our associated study [2] we demonstrate that both up- and down-regulated genes can be direct Brakeless targets. Our results indicate that the co-repressor and co-activator activities of Brakeless may result in distinct biological responses. The microarray data complies with MIAME guidelines and is deposited in GEO under accession number GSE60048.
Journal: Data in Brief - Volume 5, December 2015, Pages 134–137