کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
175627 | 458915 | 2016 | 10 صفحه PDF | دانلود رایگان |

Extending our previous work with 2-nitroimidazole-indocyanine dye-conjugate 4, we prepared the 4-nitroimidazole-piperazine-indocyanine derivative (6). We also prepared imidazole derivative 5 as a control. We compared the in vivo hypoxia targeting performance of both 5 and 6 with the previously tested 4, and 6 showed a higher fluorescent intensity after 15 min post-injection, about 1.5-fold higher than 4 and 2.5-fold higher than 5. Cells treated with 6 under hypoxic conditions showed a higher fluorescence yield when compared to the cells kept under normoxic conditions. All findings were supported with fluorescence images of histological sections of tumor samples using a Li-COR scanner and an immunohistochemistry technique for tumor hypoxia.
Figure optionsDownload as PowerPoint slide
Journal: Dyes and Pigments - Volume 126, March 2016, Pages 251–260