کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
175627 458915 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a 4-nitroimidazole indocyanine dye-conjugate and imaging of tumor hypoxia in BALB/c tumor-bearing female mice
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Synthesis of a 4-nitroimidazole indocyanine dye-conjugate and imaging of tumor hypoxia in BALB/c tumor-bearing female mice
چکیده انگلیسی

Extending our previous work with 2-nitroimidazole-indocyanine dye-conjugate 4, we prepared the 4-nitroimidazole-piperazine-indocyanine derivative (6). We also prepared imidazole derivative 5 as a control. We compared the in vivo hypoxia targeting performance of both 5 and 6 with the previously tested 4, and 6 showed a higher fluorescent intensity after 15 min post-injection, about 1.5-fold higher than 4 and 2.5-fold higher than 5. Cells treated with 6 under hypoxic conditions showed a higher fluorescence yield when compared to the cells kept under normoxic conditions. All findings were supported with fluorescence images of histological sections of tumor samples using a Li-COR scanner and an immunohistochemistry technique for tumor hypoxia.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 126, March 2016, Pages 251–260
نویسندگان
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