Preparation and in vitro anticancer activity comparison of photosensitive nanoparticles with different self-assemble degree

• Charge photosensitive drug can self-assemble by regulating environment ion strength.
• Self-assemble degree can be controlled by ion strength.
• Nanostructures with proper assemble degree have superior activity to monomers.

Self-assembled organic photosensitive nanoparticles have been widely used in diagnosis and therapeutic of cancer. In this manuscript, a simple but effective method to regulate the self-assemble degree of small charge photosensitive drug was demonstrated. Studies indicated that the ordered self-assembled nanostructures with proper assemble degree can significantly enhances the reactive oxygen species generation efficiency and, thereby, improve the in vitro photodynamic efficacy comparing with the corresponding monomers.

A simple but effective method to regulate the self-assemble degree of small charge photosensitive drug was demonstrated to improve its photodynamic activity.Figure optionsDownload as PowerPoint slide