کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1758956 1019258 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The preliminary evaluation of a 1 MHz ultrasound probe for measuring the elastic anisotropy of human cortical bone
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
The preliminary evaluation of a 1 MHz ultrasound probe for measuring the elastic anisotropy of human cortical bone
چکیده انگلیسی


• We developed an ultrasound probe for measurements at the tibial shaft.
• The device can reproducibly measure the anisotropy of sound velocity in cortical bone.
• Sound velocity and anisotropy are expected to be indicators of bone strength.
• Anisotropies of two excised human tibiae were significantly different.

Our objective is to evaluate an ultrasound probe for measurements of velocity and anisotropy in human cortical bone (tibia). The anisotropy of cortical bone is a known and mechanically relevant property in the context of osteoporotic fracture risk. Current in vivo quantitative ultrasound devices measuring the velocity of ultrasound in long bones can only be applied in the axial direction. For anisotropy measurements a second direction for velocity measurements preferably perpendicular to the axial direction is necessary. We developed a new ultrasound probe which permits axial transmission measurements with a simultaneous second perpendicular direction (tangential). Anisotropy measurements were performed on isotropic and anisotropic phantoms and two excised human female tibiae (age 63 and 82). Anisotropy ratios (AI; ratio of squared ultrasound velocities in the two directions) were for the isotropic phantom 1.06 ± 0.01 and for the anisotropic phantom 1.14 ± 0.03 (mean ± standard deviation). AI was 1.83 ± 0.29 in the tibia from the older donor and 1.37 ± 0.18 in the tibia from the younger donor. The AIs were in the expected range and differed significantly (p < 0.05, t-test) between the tibiae. Measured sound velocities were reproducible (mean standard deviation of short time precision of both channels for phantom measurements 31 m/s) and in agreement with reported velocities of the phantom material. Our results document the feasibility of anisotropy measurements at long bones using a single probe. Further improvements in the design of the probe and tests in vivo are warranted. If this approach can be evaluated in vivo an additional tool for assessing the bone status is available for clinical use.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics - Volume 54, Issue 1, January 2014, Pages 4–10
نویسندگان
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