Dual-frequency tissue harmonic suppression using phase-coded pulse sequence: Proof of concept using a phantom

► Dual-frequency harmonic imaging provides nonlinear detection of microbubble contrast agents at both f0 and 2f0 frequencies. ► The 2f0 second harmonic and the f0 inter-modulation harmonic signals should be simultaneously suppressed to improve CTR. ► A novel phase-coded DF pulse sequence comprising of transmit phase in the equidistant set of {−2π/3, 0, +2π/3} is proposed. ► Experimental results indicate that tissue harmonic suppression by about 20 dB can be achieved with the phase-coded sequence.