An efficient and practical synthesis of bis(indolyl)methanes catalyzed by N-sulfonic acid poly(4-vinylpyridinium) chloride

• Introduction of an efficient solid acid for the synthesis of bis(indolyl)methane derivatives.
• Application of solvent-free conditions, use of grinding stone method and minimization of the amount of organic solvent used.
• No side reactions, ease of preparation and handling of the catalyst, facilitate the separation of the product from the catalyst.
• High yields, short reaction times, effective and reusability catalyst.

A mild, simple and convenient procedure for the synthesis of bis(indolyl)methane derivatives was described using N-sulfonic acid poly(4-vinylpyridinium) chloride as an efficient, cheap, and reusable catalyst under mild conditions.

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