کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
176737 | 458954 | 2013 | 10 صفحه PDF | دانلود رایگان |
Six novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. The incorporation efficiency and solubility during a time period were evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators. The photobiological potentials were evaluated on human nasopharynx KB carcinoma cells. None of the formulations studied showed cytotoxic effects in the absence of light, whereas all of them showed good performance after irradiation. The 50% inhibition of cell proliferation (IC50) was in the range of 0.21–0.47 μM for Pc9-loaded liposome formulations. A lysosomal localization was found for S-PEG as well as for S.
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► Six novel liposomal formulation of Pc9 were investigated for PDT.
► Pc9 liposomal formulations were efficient singlet oxygen quantum yield generators.
► All Pc9 formulations showed photocytotoxic activity against KB cells.
► A preferential localization in lysosomes was established for the Pc9 formulations.
Journal: Dyes and Pigments - Volume 96, Issue 3, March 2013, Pages 626–635