کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
177801 | 459001 | 2008 | 7 صفحه PDF | دانلود رایگان |

Reversible biosensors based on 2-(3,5-dinitrophenyl)-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone (CPO-I), 2-(4-nitrophenyl)-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone (CPO-II) and 2-(4-tolyl)-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone (CPO-III) derivatives immobilized in a polyvinylchloride matrix, doped with acetylcholinesterase, have been developed. The biosensors were calibrated for acetylcholine as neurotransmitter and the potent, selective and reversible cholinesterase inhibitor, donepezil ((±)-2-[(1-benzyl-piperidine-4-yl)ethyl]-5,6-dimetoxyindan-1-one hydrochloride). The photophysical parameters of all derivatives were also examined in PVC in which medium, they exhibited excellent photostability.
Journal: Dyes and Pigments - Volume 76, Issue 3, 2008, Pages 792–798