کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
177841 | 459003 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The synthesis and properties of unsymmetrical 3,7-diaminophenothiazin-5-ium iodide salts: Potential photosensitisers for photodynamic therapy
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The synthesis and properties of unsymmetrical 3,7-diaminophenothiazin-5-ium iodide salts: Potential photosensitisers for photodynamic therapy The synthesis and properties of unsymmetrical 3,7-diaminophenothiazin-5-ium iodide salts: Potential photosensitisers for photodynamic therapy](/preview/png/177841.png)
چکیده انگلیسی
A series of unsymmetrical 3,7-(N,N-disubstituted-amino)-phenothiazin-5-ium iodides have been prepared by stepwise reaction of secondary amines with phenothiazin-5-ium tetraiodide hydrate. The singlet oxygen generating efficiencies and polarity characteristics of the dyes are compared with those of Methylene Blue, and the factors influencing the potential value of these compounds as photosensitisers for photodynamic therapy are discussed. Preliminary data for the in vivo anti-tumour efficacy of the compounds suggest that high lipophilicity is an important requirement for high activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 71, Issue 2, 2006, Pages 153–160
Journal: Dyes and Pigments - Volume 71, Issue 2, 2006, Pages 153–160
نویسندگان
Stephen A. Gorman, Andrea L. Bell, John Griffiths, Dave Roberts, Stanley B. Brown,