A novel device of array nanochannels integrated electrochemical detector for detection of amyloid β aggregation and inhibitor screening

• An array nanochannels of porous anodic alumina based bioanalysis device was developed.
• This device integrated with electrochemical detector is used to detect aggregation of Aβ.
• Copper ions induced Aβ aggregation and the inhibition effect of EDTA are observed in nanochannels.
• The method shows potential application in drug screening and efficient treatment of Alzheimer's disease.

A device of array nanochannels integrated with sensitive electrochemical detector has been designed to detect amyloid β (Aβ) peptide aggregation and inhibitor screening. Owing to the highly amplification capacity of array nanochannels, the change in ionic current upon Aβ peptide aggregation and inhibitor disaggregation can be easily monitored at micro-ampere level.

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