New stochastic microsensors based on oleamides

• New stochastic microsensors based on graphite paste were designed.
• Six oleamides were used as modifiers for graphite paste.
• Carcinoembryonic antigen was used as model analyte.
• High reliabilities and sensitivities were recorded for the new microsensors.

Six oleamides: oleoylethanolamide, (Z)-N-[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]-9octadecenamide, N-phenethyloleamide, N-[2-(4-methoxyphenyl)ethyl]oleamide, N-[1]naphthyloleamide, N-cyclohexyloleamide were synthesized and used as modifiers for the design of new stochastic microsensors based on graphite paste. Carcinoembryonic antigen (CEA) was used as a model analyte to prove the stochastic behavior of the microsensors. CEA was determined directly from whole blood samples with recoveries higher than 94.00%, favorizing pattern recognition of CEA in whole blood samples. The most sensitive stochastic microsensor was the one based on the physical immobilization of N-[2-(4-methoxyphenyl)ethyl]oleamide in graphite paste.