Strongly enhanced guanine electrooxidation caused by temperature induced volume-phase- and conformational transitions in DNA/PNIPA composites

• Nanostructured ss- and dsDNA/PNIPA composites were synthesized.
• Volume phase transition and DNA conformational transformation occur simultaneously.
• Anodic guanine current significantly increases in physiological temperatures.
• Both transformations are switchable.

Nanostructured DNA/poly(N-isopropylacrylamide) PNIPA composites were synthesized. DNA was noncovalently entrapped. A strongly enhanced electrooxidation current of DNA guanine was obtained due to cooperation of two temperature switchable effects: the volume phase transition of composites and conformational transition of DNA structure.

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