PEGylation of platinum bio-electrodes

Controlling protein interactions at the implanted electrode interface is becoming an important strategy for the management of foreign body responses that have proven to be detrimental to the long-term performance of neural prosthesis. In this study, PEGylation was conducted on platinum bio-electrodes to render the surface protein-resistant. The PEGylated electrode was investigated using a quartz crystal microbalance-dissipation, electrochemical impedance spectroscopy and cyclic voltammetry.

► PEGylation of platinum bio-electrodes
► Nano-sized, highly hydrated and permeable PEG adlay immobilized on Pt electrodes
► Excellent resistance to protein adsorption at the PEGylated electrode interface
► Moderate increase in in vitro impedance by PEGylation