کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1798896 | 1524841 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Magnetic poly(d,l-lactide) nanoparticles loaded with aliskiren: A promising tool for hypertension treatment
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study anti-hypertensive drug called aliskiren was encapsulated in magnetic poly(d,l-lactide) nanoparticles by the modified nanoprecipitation method. The effect of magnetite and drug concentrations on the size distribution and zeta potential of polymer nanoparticles was investigated. The optimized loadings were as follows: theoretical magnetite loading was 20Â mg/100Â mg polymer nanoparticles and aliskiren was encapsulated in magnetic poly(d,l-lactide) nanoparticles at theoretical loading 0.6Â mg aliskiren/100Â mg magnetic polymer nanoparticles. The physicochemical characteristics of nanoparticles were studied, with spherical shape of nanoparticles sized between 58 and 227Â nm being one of the observed results. Differential scanning calorimetry and infrared spectroscopy confirmed that aliskiren was successfully identified in the magnetic poly(d,l-lactide) nanoparticles. The in vivo experiments indicated that encapsulated aliskiren decreased blood pressure of the studied male spontaneously hypertensive rat even more significantly than common administered drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 380, 15 April 2015, Pages 280-284
Journal: Journal of Magnetism and Magnetic Materials - Volume 380, 15 April 2015, Pages 280-284
نویسندگان
Iryna Antal, Martina Kubovcikova, Vlasta Zavisova, Martina Koneracka, Olga Pechanova, Andrej Barta, Martina Cebova, Vitaliy Antal, Pavel Diko, Martina Zduriencikova, Michal Pudlak, Peter Kopcansky,