کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1800140 1024508 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Magnetic, optical and relaxometric properties of organically coated gold–magnetite (Au–Fe3O4) hybrid nanoparticles for potential use in biomedical applications
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
Magnetic, optical and relaxometric properties of organically coated gold–magnetite (Au–Fe3O4) hybrid nanoparticles for potential use in biomedical applications
چکیده انگلیسی

We present the magnetic, optical and relaxometric properties of multifunctional Au–Fe3O4 hybrid nanoparticles (HNPs), as possible novel contrast agents (CAs) for magnetic resonance imaging (MRI). The HNPs have been synthesized by wet chemical methods in heterodimer and core–shell geometries and capped with oleylamine. Structural characterization of the samples have been made by X-ray diffraction and transmission electron microscopy, while magnetic properties have been investigated by means of Superconducting Quantum Interference Device-SQUID magnetometry experiments. As required for MRI applications using negative CAs, the samples resulted superparamagnetic at room temperature and well above their blocking temperatures. Optical properties have been investigated by analyzing the optical absorbtion spectra collected in UV–visible region. Relaxometric measurements have been performed on organic suspensions of HNPs and Nuclear Magnetic Resonance (NMR) dispersion curves have been obtained by measuring the longitudinal 1/T1 and transverse 1/T2 relaxation rates of solvent protons in the range 10 kHz/300 MHz at room temperature. NMR relaxivities r1 and r2 have been compared with ENDOREM®, one of the commercial superparamagnetic iron oxide based MRI contrast agents. MRI contrast enhancement efficiencies have been investigated also by examining T2-weighted MR images of suspensions. The experimental results suggest that the nanoparticles' suspensions are good candidates as negative CAs.


► Au–Fe3O4 superparamagnetic Hybrid NanoPrticles (HNPs) enhance contrast in MRI.
► HNPs are expected to have optical activities through observed SPR phenomena.
► HNPs have relatively high magnetic anisotropy originating from Au/Fe3O4 interface.
► Magnetic dipolar interactions have been observed between particles in powders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 324, Issue 15, August 2012, Pages 2373–2379
نویسندگان
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