Enhancement of the efficiency of magnetic targeting for drug delivery: Development and evaluation of magnet system

Deep magnetic capture and clinical application are the current trends for magnetic targeted drug delivery system. More promising and possible strategies are needed to overcome the current limitations and further improve the magnetic targeting technique. Recent advances in the development of targeting magnet system show promise in progressing this technology from the laboratory to the clinic. Starting from well-known basic concepts, current limitations of magnetic targeted drug delivery system are analyzed. Meanwhile, the design concepts and evaluations of some effective improvements in magnet system are discussed and reviewed with reference to (i) reasonable design of magnet system; (ii) control modes of magnet system used to generate dynamical magnetic fields; and (iii) magnetic field driving types.

Research Highlights
► The current limitations of MTDDS for deep capture and clinical application are analyzed.
► The development of magnet system shows promise in progressing MTDDS to clinical application.
► The design concepts and evaluations of improvements in magnet system are reviewed and discussed.
► The key to improve magnet system lies in controllable magnets and different excitations.