کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1802483 1024598 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration
چکیده انگلیسی

Magnetic nanoparticles have been investigated for biomedical applications for more than 30 years. The development of biocompatible nanosized drug delivery systems for specific targeting of therapeutics is imminent in medical research, especially for treating cancer and vascular diseases. We used drug-labeled magnetic iron oxide nanoparticles, which were attracted to an experimental tumor in rabbits with an external magnetic field (magnetic drug targeting, MDT). Aim of this study was to detect and quantify the biodistribution of the magnetic nanoparticles by magnetorelaxometry. The study shows higher amount of nanoparticles in the tumor after intraarterial application and MDT compared to intravenous administration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 321, Issue 10, May 2009, Pages 1465–1468
نویسندگان
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