کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1804231 1024644 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Labeling of macrophages using bacterial magnetosomes and their characterization by magnetic resonance imaging
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
Labeling of macrophages using bacterial magnetosomes and their characterization by magnetic resonance imaging
چکیده انگلیسی

This work investigated macrophages labeled with magnetosomes for the possible detection of inflammations by MR molecular imaging. Pure magnetosomes and macrophages containing magnetosomes were analyzed using a clinical 1.5 T MR-scanner. Relaxivities of magnetosomes and relaxation rates of cells containing magnetosomes were determined. Peritonitis was induced in two mice. T1, T2 and T2* weighted images were acquired following injection of the probes. Pure magnetosomes and labeled cells showed slight effects on T1, but strong effects on T2 and T2* images. Labeled macrophages were located with magnetic resonance imaging (MRI) in the colon area, thus demonstrating the feasibility of the proposed approach.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Magnetism and Magnetic Materials - Volume 311, Issue 1, April 2007, Pages 454–459
نویسندگان
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