Electrochemical determination of whole blood clotting time by using nanodot arrays

Simple and cost-effective process for the fabrication of a nanodot strip which can electrochemically determine blood coagulation time was described in detail. We observed that the beginning of blood coagulation on the nanodot surface gives rise to increase in resistance against current flow, leading to suddenly increase in potential when constant current is applied between the nanodot electrodes. Interestingly, such dramatic increase in potential was not observed in the plain surface and non-controlled rough surface.