کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1806115 1025185 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and tumor expression of metalloproteases and their inhibitors in invasive breast cancer
ترجمه فارسی عنوان
رابطه بین ویژگی های مورفولوژیکی و الگوهای جنبشی افزایش تصویربرداری رزونانس مغناطیسی پویای پستان و بیان تومور متالوپروتئاز و مهارکننده های آنها در سرطان های مهاجم پستان
کلمات کلیدی
MMP؛ TIMP؛ MR؛ فیبروبلاست های مرتبط با تومور
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی

AimMatrix metalloproteases (MMPs) expression and their inhibitors (TIMPs) play an important role in tumor physiopathology, so we investigated the relationship between the magnetic resonance (MR) and MMPs/TIMPs expression by breast carcinomas.Materials and methodsMRI parameters of 64 breast carcinomas were investigated. An immunohistochemical study was also performed in these cases using tissue microarrays and specific antibodies against MMP-1, MMP-2, MMP-7, MMP-9, MMP-11, MMP-13, MMP-14, TIMP-1, TIMP-2 and TIMP-3.ResultsTumors with spiculated margins had a high global (score) values of MMP-1 or MMP-7, and high expression of TIMP-3 by tumor cells. Heterogeneous tumors had a higher score values of MMP-1, MMP-13, TIMP-2 or TIMP-3, and frequent expression of TIMP-3 by tumor cells. Tumors showing fast enhancement, had higher score values of MMP-1 or MMP-11. Associations between washout curve (type III) and MMP-1, MMP-11, MMP-13 and TIMP-1 expression by tumor cells, were found.ConclusionsMRI features may predict in some grade the expressions of MMPs/TIMPs in breast tumors, which might to contribute to a better biological characterization of breast cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 34, Issue 8, October 2016, Pages 1107–1113
نویسندگان
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