کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
180970 459393 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermal stability of diazonium derived and thiol-derived layers on gold for application in genosensors
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Thermal stability of diazonium derived and thiol-derived layers on gold for application in genosensors
چکیده انگلیسی

DNA analysis using variable temperature technologies such as melting curve analysis, high temperature mutant discrimination or immobilised PCR relies upon the use of immobilised probes that need to be stable over a wide temperature range. In this work a comparison of the thermal stability of gold surfaces modified with alkanethiol and diazonium salt derived layers is presented. Electrochemical impedance spectroscopy and cyclic voltammetry were used to characterize the electrode arrays. The applicability of the surfaces for DNA sensing was demonstrated following the thermal treatment, with the diazonium-modified surface being markedly more stable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochemistry Communications - Volume 12, Issue 8, August 2010, Pages 1045–1048
نویسندگان
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