کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1855611 | 1529400 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metachronous medulloblastoma and glioblastoma: Implications for clinical and technical aspects of re-irradiation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک هسته ای و انرژی بالا
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چکیده انگلیسی
A seven-year-old male underwent surgical resection and chemoradiation for average risk medulloblastoma; twelve years later, the presence of a necrotic and infiltrative mass in the same area and invading the brainstem prompted a subtotal resection. Pathology was indicative of glioblastoma. He was then treated with concurrent temozolomide and using biologically effective dose calculations for gross residual tumor tissue in the brainstem as well as brainstem tolerance, a radiotherapy dose of 3750Â cGy was chosen, fractionated in twice-daily fractions of 125Â cGy each. The gross tumor volume was expanded with a 5Â mm margin to the planning target volume, which was also judiciously subtracted from the normal brainstem. He completed his radiotherapy course with subsequent imaging free of residual tumor and continued adjuvant temozolomide and remains under follow-up surveillance. This case underscores the rarity of metachronous medulloblastoma and glioblastoma, of which only five known cases heretofore have been described. We discuss the technicalities of radiotherapy planning in this patient, including common hurdles for radiation oncologists in similar patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reports of Practical Oncology & Radiotherapy - Volume 21, Issue 1, JanuaryâFebruary 2016, Pages 84-89
Journal: Reports of Practical Oncology & Radiotherapy - Volume 21, Issue 1, JanuaryâFebruary 2016, Pages 84-89
نویسندگان
Vivek Verma, Rajesh R. Kulkarni, Abhijeet R. Bhirud, Nathan R. Bennion, Rodney D. McComb, Chi Lin,