کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1855733 | 1529427 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma: 15-Year results Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma: 15-Year results](/preview/png/1855733.png)
BackgroundInvasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease.AimThe current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC.Material and methodsStudy includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n = 163) or BCS (n = 72). 50 Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group.ResultsPatients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62% vs. 70%; p, 0.2017) and breast cancer-specific (62% vs. 70%; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10% with and 53% without RT at 15 years (relative risk [RR], 0.10; p < 0.0001). In the mastectomy group the actuarial rate of chest wall recurrences was 16% with and 13% without RT at 15 years (RR, 1.45; p, 0.3965). Isolated ipsilateral in breast recurrence did not (RR, 1.73; p, 0.2767) but isolated chest-wall recurrence did (RR, 2.65; p, 0.0089) adversely affect cause-specific survival.ConclusionBreast cancer specific survival is not affected by the type of surgical treatment. BCS and RT is a safe option to control local disease in patients with ILC.
Journal: Reports of Practical Oncology & Radiotherapy - Volume 16, Issue 6, November–December 2011, Pages 227–231